Anti-SULT1A1 Antibody

Cat: 11658-RP02
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Anti-SULT1A1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SULT1A1 Antibody
Validated applications
WB,ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human SULT1A1
Immunogen
Recombinant Human SULT1A1 protein (Catalog#11658-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human SULT1A1 (rh SULT1A1; Catalog#11658-H07E; P50225-1; Glu 2-Leu 295). SULT1A1 specific IgG was purified by Human SULT1A1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SULT1A1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SULT1A1 Antibody (Rabbit Polyclonal antibody) Images
Human SULT1A1 Immunohistochemistry(IHC) 3535
Immunochemical staining of human SULT1A1 in human prostatic carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human SULT1A1 Immunohistochemistry(IHC) 3537
Immunochemical staining of human SULT1A1 in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Human SULT1A1 Western blot (WB) 13433

Anti-SULT1A1 rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:34 kDa

Observed band size:35 kDa

Anti-SULT1A1 Antibody Alternative Names
Anti-HAST1/HAST2 Antibody;Anti-P-PST Antibody;Anti-PST Antibody;Anti-ST1A1 Antibody;Anti-ST1A3 Antibody;Anti-STP Antibody;Anti-STP1 Antibody;Anti-TSPST1 Antibody
SULT1A1 Background Information

Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. SULTs may be involved in the individual genetic disposition, species differences, and organotropisms for toxicological effects of chemicals. Particularly SULT1A1 (Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1), a member of the sulfotransferase 1 subfamily, which is a major pathway for drug metabolism in humans. Humans have at least 10 functional SULT genes. There has been an explosion in information on sulfotransferase polymorphisms and their functional consequences. An Arg213His polymorphism in SULT1A1 has a strong influence on the level of enzyme protein and activity in platelets, which have been widely used for phenotyping. Statistically significant associations were observed between the SULT1A1 genotype (Arg213His) and age, obesity and certain neoplasias (mammary, pulmonary, esophageal and urothelial cancer). Furthermore, the polymorphism of the SULT1A1 may be closely associated with breast cancer.

Full Name
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
References
  • Coughtrie MW. 2002. Sulfation through the looking glass--recent advances in sulfotransferase research for the curious. Pharmacogenomics J. 2(5): 297-308.
  • Klaassen CD, et al. (1998) Regulation of sulfotransferase mRNA expression in male and female rats of various ages. Chem Biol Interact. 109(1-3): 299-313.
  • Glatt H. (2000) Sulfotransferases in the bioactivation of xenobiotics. Chem Biol Interact. 129(1-2): 141-70.
  • Glatt H, et al. (2004) Pharmacogenetics of soluble sulfotransferases (SULTs). Naunyn Schmiedebergs Arch Pharmacol. 369(1): 55-68.
  • Hebbring SJ, et al. (2008) Sulfotransferase gene copy number variation: pharmacogenetics and function. Cytogenet Genome Res. 123(1-4): 205-10.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SULT1A1 Antibody Mouse Monoclonal WB,ELISA,IP 11658-MM03
    Anti-SULT1A1 Antibody Rabbit Monoclonal ELISA 11658-R029
    Anti-SULT1A1 Antibody Rabbit Monoclonal IHC-P 11658-R034
    Anti-SULT1A1 Antibody Rabbit Polyclonal ELISA 11658-RP01
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