STXBP3 (UNC-18C)

Together with STX4 and VAMP2, STXBP3 may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

STXBP3 (UNC-18C) Related Areas

Neuroscience>>Synaptic Protein>>STXBP3/UNC-18C

STXBP3 (UNC-18C) Alternative Names

STXBP3, UNC-18C, MUNC18-3, MUNC18C, PSP [Homo sapiens]

Stxbp3, Stxbp3a, RP23-217I18.5, MGC86097, Munc-18c, Sxtbp3, Unc18-3 [Mus musculus]

Summaries for STXBP3 (UNC-18C)

Wikipedia summary for STXBP3 (UNC-18C):

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.

Human STXBP3 (UNC-18C) Protein General Information

 

• Protein names: Syntaxin-binding protein 3
  Short name=STXBP3
• Sequence length: 592 AA.
• Sequence similarities: Belongs to the STXBP/unc-18/SEC1 family.
• Post-translational modification: Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.
• Subunit structure: Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion . Interacts with STX4.
• Subcellular location: Cytoplasm › cytosol. Cell membrane. Note: In platelets, predominantly cytosolic. Low amounts membrane-associated.
• Tissue specificity: Megakaryocytes and platelets.

General information above from UniProt

Function for STXBP3 (UNC-18C) Protein

UniProtKB:

Together with STX4 and VAMP2, STXBP3 may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

Genatlas:

• STXBP3 is involved in intracellular vesicular transport
• STXBP3 regulates vesicle docking
• STXBP3 may preferentially regulate the fusion of secondary granules
• STXBP3 plays an essential positive role in second-phase glucose-stimulated insulin secretion, suggesting novel roles for STXBP3 in granule localization to the plasma membrane as well as in triggering STX4 accessibility to VAMP2 at a step preceding vesicle docking/fusion
• STXBP3 plays a separate role in the polarized localization of STX4
• STXBP3 stabilizes syntaxin 4 at the plasma membrane

Homology for human STXBP3 (UNC-18C)

• homolog to rattus Stxbp3 (90.7 pc)
• homolog to murine Stxbp3a (91.5 pc)