STK16 (PKL12)

STK16 is membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. STK16 also autophosphorylates. STK16 may be involved in secretory vesicle trafficking or intracellular signaling. STK16 may have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. STK16 may be involved in TGF-beta signaling. STK16 is able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

STK16 (PKL12) Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>STK16/PKL12

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>STK16/PKL12

STK16 (PKL12) Alternative Names

STK16, PKL12, FLJ39635, KRCT, MGC16211, MPSK, TSF1 [Homo sapiens]

Stk16, PKL12, EDPK, Krct [Mus musculus]

Summaries for STK16 (PKL12)

Wikipedia summary for STK16 (PKL12):

Serine/threonine-protein kinase 16 is an enzyme that in humans is encoded by the STK16 gene.

Human STK16 (PKL12) Protein General Information

 

• Protein names: Serine/threonine-protein kinase 16
  Short name=STK16
• Sequence length: 305 AA.
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
  ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
• Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  Contains 1 protein kinase domain.
• Post-translational modification: Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.
  It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.
• Subunit structure: Monomer. Interacts with DRG1 (via its N-terminal); the interaction phosphorylates DRG1.
• Subcellular location: Cytoplasm › perinuclear region. Membrane; Lipid-anchor . Note: Associates with Golgi and Golgi-derived vesicles
• Tissue specificity: Ubiquitously expressed at very low levels.
• Sequence caution: The sequence AAV38392.1 differs from that shown. Reason: Frameshift at position 305.
  The sequence CAA06700.1 differs from that shown. Reason: Frameshift at position 305.

General information above from UniProt

Function for STK16 (PKL12) Protein

UniProtKB:

STK16 is membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. STK16 also autophosphorylates. STK16 may be involved in secretory vesicle trafficking or intracellular signaling. STK16 may have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. STK16 may be involved in TGF-beta signaling. STK16 is able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Genatlas:

• STK16 is autophosphocylation

Homology for human STK16 (PKL12)

• homolog to murine Stk16