Anti-LOK Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human STK10 / LOK protein (Catalog#11724-H07E)
Produced in rabbits immunized with purified, recombinant Human STK10 / LOK (rh STK10 / LOK; Catalog#11724-H07E; NP_005981.3; Arg 18-Glu 317). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-LOK Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-LOK Antibody Alternative Names
Anti-LOK Antibody;Anti-PRO2729 Antibody
LOK Background Information
Serine / threonine-protein kinase 10, also known as Lymphocyte-oriented kinase, STK10 and LOK, which belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE20 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste20 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK10 is similar to several known polo-like kinase kinases. It can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. STK10 can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. Stk10 can associate with Plk1 in cells and furthermore can phosphorylate Plk1. It can also act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.
serine/threonine kinase 10
Kuramochi S, et al., 1997, J. Biol. Chem. 272 (36): 22679-84. Kuramochi S, et al., 1999, Immunogenetics. 49 (5): 369-75. Walter, SA. et al., J Biol Chem 2003, 278 (20):18221-8.