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STIM1 / GOK Antibody, Rabbit PAb, Antigen Affinity Purified

  • STIM1 / GOK Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
  • STIM1 / GOK Antibody, Rabbit PAb, Antigen Affinity Purified
  • STIM1 / GOK Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • STIM1 / GOK Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Human STIM1 Antibody Product Information
Immunogen:Recombinant Human STIM1 protein (Catalog#11434-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Human STIM1 (rh STIM1; Catalog#11434-H08H; NP_003147.2; Met 1-Asp 213). STIM1 specific IgG was purified by human STIM1 affinity chromatography .
Human STIM1 Antibody WB Application Image
Human STIM1 Antibody IHC Application Image
STIM1 / GOK Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human STIM1 in human breast carcinoma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
STIM1 / GOK Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human STIM1 in human placenta with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Human STIM1 Antibody IP Application Image
Other STIM1 Antibody Products
STIM1 Background

Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I  membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human primary cells and tumor cell lines. It contains one EF-hand domain and one SAM (sterile alpha motif) domain. STIM1 / GOK plays a role in mediating Ca2+ influx following depletion of intracellular Ca2+ stores. It acts as Ca2+ sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+ depletion, STIM1 / GOK translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A / ORAI1. Transfection of STIM1 / GOK into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of rhabdomyosarcomas and rhabdoid tumors. Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) which is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels.

Human STIM1 References
  • Sabbioni S. et al., 1997, Cancer Res. 57: 4493-7.
  • Manji S.S. et al., 2000, Biochim. Biophys. Acta 1481: 147-55.
  • Williams R.T. et al., 2002, Biochim. Biophys. Acta. 1596: 131-7.
  • Spassova M.A. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 4040-5.
  • Parvez S. et al., 2008, FASEB J. 22: 752-61.
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