STAT6

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-?B and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggest that the direct interaction between Stat6 and NF-?B may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-?B.

STAT6 Related Areas

Cancer>>Apoptosis>>Bcl-2 Family>>STAT6

Signal Transduction>>Transcription Factor & Regulator>>STAT6

STAT6 Alternative Names

D12S1644, IL-4-STAT, STAT6B, STAT6C [Homo sapiens]

signal transducer and transcription activator 6 [Mus musculus]

Summaries for STAT6

Entrez Gene summary for STAT6:

The protein encoded by STAT6 gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Wikipedia summary for STAT6:

STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.
In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.

Human STAT6 Protein General Information

 

• Protein names: Signal transducer and activator of transcription 6
  Short name=STAT6
• Sequence length: 847 AA.
• Domain: SH2 domain
• Sequence similarities: Belongs to the transcription factor STAT family.
  Contains 1 SH2 domain.
• Post-translational modification: Tyrosine phosphorylated following stimulation by IL-4 and IL-3.
• Subunit structure: Forms a homodimer or a heterodimer with a related family member . Interacts with NCOA1 via its C-terminal LXXLL motif.
• Subcellular location: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

General information above from UniProt

Function for STAT6 Protein

UniProtKB:

STAT6 carries out a dual function: signal transduction and activation of transcription. STAT6 is involved in interleukin-4 signalling.

Genatlas:

• STAT6 is involved in signaling from the leptin receptor
• STAT6 is critical regulator of transcription for interleukin-4 (IL4)-induced genes
• STAT6 is survival factor in prostate cancer and regulates the genetic transcriptional program that is responsible for prostate cancer progression
• STAT6 recruits CREBBP and chromatin-modifying activities to the promoter
• With its IL4-signalling pathway are critical for the expression of Th2 effector immune responses in peripheral tissues such as the skin, lung and gut

Homology for human STAT6

• homolog to C.elegans Y51h4a17