STAT4 Protein Price Inquiry ( Available Sizes )
STAT4 Protein Product Information
||A DNA sequence encoding the human STAT4 (Q14765) (Met 1- Glu 748) was expressed, with a polyhistidine tag at the N-terminus.
STAT4 Protein QC Testing
||> 85 % as determined by SDS-PAGE.
||< 1.0 EU per μg of the protein as determined by the LAL method
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The recombinant human STAT4 consists of 767 amino acids and predicts a molecular mass of 88 kDa. It migrates as an approximately 70 KDa band in SDS-PAGE under reducing conditions.
||Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 20%gly, 0.5mM DTT
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
STAT4 Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
STAT4 Protein Related Products & Topics
STAT4 Protein Description
The STAT protein 4 (Signal Transducer and Activator of Transcription, or Signal Transduction and transcription, or STAT4) is one STAT family member that specifically mediate signals that emanate from the IL-12 receptors and play a specific role in lymphocyte function. STAT4 was initially cloned as a result of its homology with STAT1 and is widely expressed, although it is only tyrosine- or serine- phosphorylated after stimulation of T cells with interleukin (IL) -12 and IFN-α. STAT4 plays an important role in Th1 immune responses. STAT4 is activated after IL-12 interacts with the IL-12 receptor, including transcription of IFN-λ. Studies has documented the association of a common STAT4 haplotype (tagged by rs7574865) with risk for rheumatoid arthritis (RA) and systemic lupus erythematosus in both Asian and White populations.
- Thierfelder WE. et al., 1996, Nature. 382 (6587): 171-4.
- Hye-Soon L. et al., 2007, Mol Med. 13 (9-10): 455-60.
- Chitnis T. et al., 2001, J Clin Invest. 108 (5): 739-47.