SPN (CD43)

SPN is one of the major glycoproteins of thymocytes and T lymphocytes. SPN plays a role in the physicochemical properties of the T-cell surface and in lectin binding. SPN presents carbohydrate ligands to selectins. SPN has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. SPN is a counter-receptor for SN/Siglec-1 . During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response .

SPN (CD43) Alternative Names

CD43, GPL115, LSN, GALGP, OTTHUMP00000123397 [Homo sapiens]

A630014B01Rik, Cd43, Galgp, Ly-48, Ly48, 3E8 antigen, B-cell differentiation antigen LP-3 [Mus musculus]

Summaries for SPN (CD43)

Entrez Gene summary for SPN (CD43):

The protein encoded by SPN gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]

OMIM - description for SPN (CD43):

Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.

Wikipedia summary for SPN (CD43):

Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.

Human SPN (CD43) Protein General Information

 

• Protein names: SPN
  Leukocyte sialoglycoprotein Sialophorin
  CD_antigen=CD43
• Sequence length: 400 AA.
• Domain: Signal
  Transmembrane
  Transmembrane helix
• Post-translational modification: Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.
• Subunit structure: Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX
• Subcellular location: Membrane; Single-pass type I membrane protein.
• Tissue specificity: Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

General information above from UniProt

Function for SPN (CD43) Protein

UniProtKB:

SPN is one of the major glycoproteins of thymocytes and T lymphocytes. SPN plays a role in the physicochemical properties of the T-cell surface and in lectin binding. SPN presents carbohydrate ligands to selectins. SPN has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. SPN is a counter-receptor for SN/Siglec-1 . During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response .

Genatlas:

• SPN is important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation
• SPN plays a role in the physicochemical properties of the T-cell surface and in lectin binding
• SPN functions potentially as a signaling molecule, sensing extracellular cues and transducing intracellular signals that modulate T-cell function
• SPN's overexpression activates TP53 and suppresses colony formation due to induction of apoptosis
• SPN is potential contributor to tumor development and the functional ARF-TP53 pathway is required for the elimination of cells with aberrant CD43 expression
• SPN is highly glycosylated transmembrane protein that regulates T cell activation
• SPN generally serves as an antiadhesive molecule to attenuate neutrophil-endothelial interactions, but when E-selectin is expressed on endothelial cells, it also plays a proadhesive role as an E-selectin ligand
• SPN is involved in the regulation of lymphocyte adhesion and activation
• SPN is inhibitor for cell adhesion
• SPN regulates multiple T-cell functions, including T-cell activation, proliferation, apoptosis, and migration
• SPN movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism
• SPN is transmembrane sialoglycoprotein involved in cell adhesion, differentiation, and apoptosis
• SPN is the UN1 antigen, peculiarly expressed in fetal tissues and several cancer tissues, including leukemic T cells, breast, and colon carcinomas