Anti-APEG1 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human SPEG / APEG-1 protein (Catalog#12472-H08E)
Produced in rabbits immunized with purified, recombinant Human SPEG / APEG-1 (rh SPEG / APEG-1; Catalog#12472-H08E; Q15772-4; Met 1-Glu 113). SPEG / APEG-1 specific IgG was purified by Human SPEG / APEG-1 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-APEG1 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-APEG1 Antibody Alternative Names
Anti-APEG-1 Antibody;Anti-APEG1 Antibody;Anti-BPEG Antibody;Anti-CNM5 Antibody;Anti-SPEGalpha Antibody;Anti-SPEGbeta Antibody
APEG1 Background Information
Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein which belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains two fibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform 1 of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 of SPEG is predominantly expressed in the aorta. Isoform 3 of SPEG appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC. Isoform 3 of SPEG may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Isoform 3 of SPEG is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.
SPEG complex locus
Hsieh C.-M., et al., 1996, J. Biol. Chem. 271:17354-17359. Manjasetty B.A., et al., 2005, BMC Struct. Biol. 5:21-21. Zhou,Y. et al., 2007, Anal Chem. 79 (15): 5826-37. Greenman C., et al., 2007, Nature. 446:153-158.