SPARCL1 Protein & Antibody

SPARC-Like 1 (hevin)

SPARCL1 Products

SPARCL1 Protein, Recombinant

Molecule	Species	Description	Cat. No
SPARCL1	Human	Recombinant Human SPARCL1 Protein	10046-H08H

SPARCL1 Antibody

Molecule	Application	Description	Cat. No
Human SPARCL1	WB, ELISA	Mouse Monoclonal Antibody	10046-MM06
Human SPARCL1	WB, ELISA	SPARCL1 Antibody, Rabbit MAb	10046-R204
Human SPARCL1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10046-RP01

SPARCL1 ELISA Kit

Molecule	Species	Description	Cat. No
Human SPARCL1	ELISA	SPARCL1 ELISA Kit	SEK10046

SPARCL1 cDNA Clone

Molecule	Species	Description	Cat. No
SPARCL1	Human	Homo sapiens SPARCL1 transcript variant 2 cDNA Clone(NM_004684.4)	HG10046-M
SPARCL1	Mouse	Mus musculus SPARCL1 cDNA Clone	MG50544-M

SPARCL1 Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>SPARCL1

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>SPARCL1

SPARCL1 Alternative Names

SPARCL1, mast9, hevin, SC1, PIG33, SPARC-like 1 (mast9, hevin), proliferation-inducing protein 33 [Homo sapiens]

Sparcl1, mast9, hevin, Sc1, Ecm2, SPARC-like 1 (mast9, hevin), extracellular matrix protein 2 [Mus musculus]

SPARCL1 Background

SPARC-like protein 1 (SPARCL1; also known as SC1, high endothelial venule protein, or hevin) is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis. SPARCL1 has antiadhesive properties, and loss of SPARCL1 expression is associated with increased proliferative activity and cell cycle progression. It is suggested that it may influence multiple cellular processes during distinct stages of brain development and function. In addition, SPARCL1 can influence the function of astroglial cells in the developing and mature central nervous system (CNS).

SPARCL1 Related Studies

1. Sullivan MM, et al. (2004) Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family. Int J Biochem Cell Biol. 36(6): 991-6.
2. Esposito I, et al. (2007) Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer. Neoplasia. 9(1): 8-17.
3. Weimer JM, et al. (2008) A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system. Glia. 56(9): 935-41.