All alpha-Synuclein reagents are produced in house and quality controlled, including 4 alpha-Synuclein Antibody, 31 alpha-Synuclein Gene, 2 alpha-Synuclein IPKit, 1 alpha-Synuclein Protein, 1 alpha-Synuclein qPCR. All alpha-Synuclein reagents are ready to use.
Recombinant alpha-Synuclein proteins are expressed by E. coli with fusion tags as Native.
alpha-Synucleinantibodies are validated with different applications, which are IHC-P, ELISA, WB, IP.
alpha-SynucleincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each alpha-Synuclein of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). In addition, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.