SMYD3

SMYD3 is histone methyltransferase. SMYD3 specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD3 binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.

SMYD3 Related Areas

Enzyme>>Methyltransferase>>SMYD3/ZMYND1/KMT3E

SMYD3 Alternative Names

SMYD3, ZMYND1, KMT3E, FLJ21080, MGC104324, ZNFN3A1, bA74P14.1 [Homo sapiens]

SMYD3, Zmynd1, 2410008A19Rik [Mus musculus]

Summaries for SMYD3

Entrez Gene summary for SMYD3:

SMYD3 gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for SMYD3 gene. [provided by RefSeq, Dec 2011]

OMIM - description for SMYD3:

SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.

Wikipedia summary for SMYD3:

SET and MYND domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.
SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.

Human SMYD3 Protein General Information

 

• Protein names: SET and MYND domain-containing protein 3
  Short name=SMYD3
• Sequence length: 428 AA.
• Domain: Zinc-finger
• Sequence similarities: Belongs to the histone-lysine methyltransferase family.
  Contains 1 MYND-type zinc finger.
  Contains 1 SET domain.
• Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
• Subunit structure: Interacts with HSPCA. Interacts with HELZ. Interacts with POLR2A; the interaction may be indirect and may be mediated by HELZ.
• Subcellular location: Cytoplasm. Nucleus. Note: Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.
• Tissue specificity: Expressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and hepatocellular carcinomas.
• Enzyme regulation: Histone methyltransferase activity strongly stimulated by HSPCA.
• Sequence caution: The sequence CAI14744.1 differs from that shown. Reason: Erroneous initiation.
  The sequence CAI16628.1 differs from that shown. Reason: Erroneous initiation.

General information above from UniProt

Function for SMYD3 Protein

UniProtKB:

SMYD3 is histone methyltransferase. SMYD3 specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD3 binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.

Genatlas:

• SMYD3 plays a role in transcriptional regulation, forming a complex with the RNA polymerase II
• SMYD3 is histone methyltransferase involved in the proliferation of cancer cells
• SMYD3 is implicated in oncogenesis, and directly trans-activates the telomerase reverse transcriptase (TERT) gene that is essential for cellular immortalization and transformation
• SMYD3 is required for maintenance of histone H3-K4 trimethylation, there by contributing to inducible and constitutive TERT expression in normal and malignant cells
• SMYD3 is histone H3-lysine 4-specific methyltransferase, involved in the regulation of gene expression and DNA replication through alteration of chromatin structure
• SMYD3 could promote breast carcinogenesis by directly regulating expression of the proto-oncogene WNT10B

Homology for human SMYD3

• ortholog to murine Smyd3
• homolog to xenopus BX847649.1