SMYD2

SMYD2 is protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. SMYD2 specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD2 has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. SMYD2 monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. SMYD2 monomethylates 'Lys-860' of RB1/RB.

SMYD2 Related Areas

Enzyme>>Methyltransferase>>SMYD2/ZMYND14/KMT3C

SMYD2 Alternative Names

SMYD2, ZMYND14, KMT3C, HSKM-B, MGC119305 [Homo sapiens]

Smyd2, Zmynd14, KMT3C, 1110020E07Rik, 4930402C15 [Mus musculus]

Summaries for SMYD2

Entrez Gene summary for SMYD2:

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]

OMIM - description for SMYD2:

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006).

Human SMYD2 Protein General Information

 

• Protein names: N-lysine methyltransferase SMYD2
• Sequence length: 433 AA.
• Domain: Zinc-finger
• Sequence similarities: Contains 1 MYND-type zinc finger.
  Contains 1 SET domain.
• Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
• Subunit structure: Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 . Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1.
• Subcellular location: Cytoplasm › cytosol . Nucleus .
• Induction: Expression is repressed by CEBPA.

General information above from UniProt

Function for SMYD2 Protein

UniProtKB:

SMYD2 is protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. SMYD2 specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD2 has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. SMYD2 monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. SMYD2 monomethylates 'Lys-860' of RB1/RB.

Genatlas:

• SMYD2 may be an histone tail methylase involved in chromatin structure
• SMYD2 catalyzes lysine methylation
• SMYD2 may function as a putative oncogene by methylating TP53 and repressing its tumor suppressive function
• SMYD2 methylates RB1 at lysine 860 (this modification permits direct binding of RB1 to the lysine methyl-binding protein L3MBTL, which may alter the function of RB1 in cells)

Homology for human SMYD2

• homolog to murine Smyd2 (93.5pc)
• homolog to rattus Smyd2 (93.8pc)
• homolog to chicken SMYD2 (86.4pc)