Acid sphingomyelinase (Protein|Antibody|cDNA Clone|ELISA Kit)

All Acid sphingomyelinase reagents are produced in house and quality controlled, including 1 Acid sphingomyelinase Antibody, 28 Acid sphingomyelinase Gene, 4 Acid sphingomyelinase Lysate, 4 Acid sphingomyelinase Protein, 2 Acid sphingomyelinase qPCR. All Acid sphingomyelinase reagents are ready to use.

Recombinant Acid sphingomyelinase proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-His, C-His.

Acid sphingomyelinaseantibodies are validated with different applications, which are ELISA.

Acid sphingomyelinasecDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Acid sphingomyelinase of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

Acid sphingomyelinase Protein (4)

Species

Acid sphingomyelinase Protein, Mouse, Recombinant (His Tag)

50749-M08B

Expression host: Baculovirus-Insect Cells

Mouse SMPD1 Protein 11887

Acid sphingomyelinase Protein, Human, Recombinant (His Tag)

11087-H08B

Expression host: Baculovirus-Insect Cells

Human SMPD1 Protein 9401

Acid sphingomyelinase Protein, Human, Recombinant (His Tag)

11087-H08B1

Expression host: Baculovirus-Insect Cells

Human SMPD1 Protein 6252

Acid sphingomyelinase Protein, Human, Recombinant (His Tag)

11087-H07B

Expression host: Baculovirus-Insect Cells

Human SMPD1 Protein 9400
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Acid sphingomyelinase Antibody (1)

Application
Clonality
Host

Anti-Acid sphingomyelinase Antibody

11087-MM09

Application: ELISA

Clonality: MAb

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Acid sphingomyelinase cDNA Clone (28)

Mouse
Rat
Human

Acid sphingomyelinase qPCR Primer (2)

Acid sphingomyelinase Lysate (4)

Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monomeric lysosomal enzyme that converts sphingomyelin (a plasma membrane lipid ) into ceramide through the removal of phosphorylcholine. This generates second messenger components that participate in signal transduction. Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPA) and type B (NPB), also known as Niemann-Pick disease classical infantile form and Niemann-Pick disease visceral form. Niemann-Pick disease is a clinically and genetically heterogeneous recessive disorder. NPB has little if any neurologic involvement and patients may survive into adulthood.

Protein
Antibody
Gene
qPCR
Lysate
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