SMAC / Diablo Protein & Antibody

Second Mitochondria-derived Activator of Caspase / Diablo homolog (Drosophila)

SMAC / Diablo Products

SMAC / Diablo Protein, Recombinant

Molecule	Species	Description	Cat. No
SMAC/Diablo	Human	SMAC/Diablo Protein, Recombinant	10339-H08E

SMAC / Diablo Antibody Products

Molecule	Application	Description	Cat. No
Human SMAC/Diablo	WB, ELISA	SMAC/Diablo Antibody, Mouse MAb	10339-MM01
Human SMAC/Diablo	WB, ELISA	SMAC/Diablo Antibody, Rabbit PAb	10339-RP01
Human SMAC/Diablo	WB, ELISA	SMAC/Diablo Antibody, Rabbit PAb (Antigen Affinity Purified)	10339-RP02

SMAC / Diablo cDNA Clone

Molecule	Species	Description	Cat. No
SMAC/Diablo	Human	Homo sapiens SMAC/Diablo transcript variant 1 cDNA Clone(NM_019887.3)	HG10339-M

SMAC / Diablo Related Areas

Cancer>>Apoptosis>>Inhibitor of Apoptosis (IAP)>>SMAC/Diablo

SMAC / Diablo Alternative Names

SMAC, DIABLO, hCG_1782202, DIABLO-S, FLJ10537, FLJ25049, SMAC [Homo sapiens]

Smac, Diablo , 0610041G12Rik, 1700006L01Rik, AU040403 [Mus musculus]

SMAC / Diablo Background

Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, both in mitochondrial and receptor pathways are presented. It has been shown that Diablo mainly interacts with IAPs in the cytochrome c/Apaf-1/caspase-9 pathway, and promotes apoptosis. Diablo is released from the mitochondria into the cytosol occurring downstream of cytochrome c release in response to apoptotic stimuli such as irradiation, DNA damage or cytotoxic drugs. In the cytosol, Smac/Diablo interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. This activity has prompted the synthesis of peptidomimetics that could potentially be used in cancer therapy. The role of Smac/DIABLO in colorectal carcinogenesis is ill defined. Data continues to accumulate to suggest that decreased levels of Smac/DIABLO may be important in chemoradiation-resistance to apoptosis in advanced colon cancer.

SMAC / Diablo Related Studies

1. Korga A, et al. (2006) Role of mitochondrial protein Smac/Diablo in regulation of apoptotic pathways Pol Merkur Lekarski. 20(119): 573-6.
2. Anguiano-Hernandez YM, et al. (2007) Smac/DIABLO and colon cancer. Anticancer Agents Med Chem. 7(4): 467-73.
3. Martinez-Ruiz G, et al. (2008) Role of Smac/DIABLO in cancer progression. J Exp Clin Cancer Res. 27: 48.