SLPI Protein

Secretory leukocyte peptidase inhibitor

SLPI Products

SLPI Protein, Recombinant

Molecule	Species	Description	Cat. No
SLPI	Human	SLPI Protein, Recombinant	10343-H07B

SLPI cDNA Clone

Molecule	Species	Description	Cat. No
SLPI	Human	Human SLPI full length cDNA Clone / ORF Clone	HG10343-M

SLPI Related Areas

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>SLPI

Immunology>>Adaptive Immunity>>B Cell>>SLPI

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>SLPI

SLPI Alternative Names

SLPI, ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4 [Homo sapiens]

Slpi, RP23-462O16.7 [Mus musculus]

SLPI Background

Secretory leukoprotease inhibitor (SLPI), also called antileukoprotease (ALP), is a 12-kDa, nonglycosylated serine protease inhibitor present in mucous secretions. It is thought to play a role in protecting the mucosae from injury associated with inflammation. SLPI is locally produced by serous cells, including bronchial submucosal glands. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. Elafin and SLPI are structurally related in that both have a fold with a four-disulfide core or whey acidic protein (WAP) domain responsible for inhibiting proteases. SLPI is a prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity.

SLPI Related Studies

1. Moreau T, et al. (2008) Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family. Biochimie. 90(2): 284-95.
2. Weldon S, et al. (2007) Innate host defense functions of secretory leucoprotease inhibitor. Exp Lung Res. 33(10): 485-91.
3. Williams SE, et al. (2006) SLPI and elafin: one glove, many fingers. Clin Sci (Lond). 110(1): 21-35.
4. Kikuchi T, et al. (1996) Regulation of secretory leukoprotease inhibitor gene expression. Nihon Rinsho. 54(2): 405-10.