SLITRK4

SLIT and NTRK-like family proteins 4 is a member of the SLIT and NTRK-like family.This protein is characterized as an integral membrane protein that has two leucine-rich repeat (LRR) domains and a carboxy-terminal domain that is partially similar to SLIT protein andTRK Neurotrophin There are six members in this family: SLITRK1, SLITRK2, SLITRK3, SLITRK4, SLITRK5, and SLITRK6. Their expression was detected mainly in the brain, but the expression profile of each SLITRK was unique. Each of these members is located in nervous system except for SLITRK6. SLITRK expression was also investigated in various types of brain tumor tissue.

SLITRK4 Related Areas

Neuroscience>>Axon Guidance>>SLITRK>>SLITRK4

SLITRK4 Alternative Names

DKFZp547M2010 [Homo sapiens]

RP23-222I1.1, 6430513G13, D930039I09Rik [Mus musculus]

Summaries for SLITRK4

Entrez Gene summary for SLITRK4:

SLITRK4 gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

OMIM - description for SLITRK4:

Members of the SLITRK family, such as SLITRK4, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1). Most SLITRKs, including SLITRK4, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).

Human SLITRK4 Protein General Information

 

• Protein names: SLIT and NTRK-like protein 4
  Short name=SLITRK4
• Sequence length: 837 AA.
• Domain: Leucine-rich repeat
  Repeat
  Signal
  Transmembrane
  Transmembrane helix
• Sequence similarities: Belongs to the SLITRK family.
  Contains 12 LRR (leucine-rich) repeats.
  Contains 2 LRRCT domains.
  Contains 1 LRRNT domain.
• Sequence caution: The sequence BAB71535.1 differs from that shown. Reason: Erroneous initiation.
• Subcellular location: Membrane; Single-pass type I membrane protein
• Tissue specificity: Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors.

General information above from UniProt

Function for SLITRK4 Protein

UniProtKB:

SLITRK4 suppresses neurite outgrowth .

Genatlas:

• SLITRK4 suppresses neurite outgrowth

Homology for human SLITRK4

• homolog to rattus LOC302473
• homolog to murine Slitrk4