Anti-SLITRK1 Antibody

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Anti-SLITRK1 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-SLITRK1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human SLITRK1
Immunogen
Recombinant Human SLITRK1 protein (Catalog#10340-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human SLITRK1 (rh SLITRK1; Catalog#10340-H08H; NP_443142.1; Met 1-Ser 616). SLITRK1 specific IgG was purified by human SLITRK1 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SLITRK1 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SLITRK1 Antibody: Alternative Names

Anti-FLJ54428 Antibody; Anti-KIAA0918 Antibody; Anti-KIAA1910 Antibody; Anti-LRRC12 Antibody; Anti-RP11-395N17.1 Antibody; Anti-SLITRK1 Antibody; Anti-TTM Antibody

SLITRK1 Background Information

SLITRK1 (Slit and Trk-like family member 1) is a integral membrane protein belonging to the SLITRK family consists of at least 6 members (SLITRK1-6). They are named and characterized by the presence of two leucine-rich repeats (LRRs) in the extracellular domain similar to those found in a secreted axonal growth-controlling protein, Slit, as well as a C-terminal domain with homology to Trk neurotrophin tyrosine kinase receptors. Expression of SLITRKs are highly restricted to neural tissues, and are identified as the neuronal components modulating the neurite outgrowth. More specifically, SLITRK1 expression is found in the mature neurons of the cerebrum, thalamus and hippocampus, and induces unipolar neurites in cultured neuronal cells. Human SLITRK1 is a 696 amino acid precursor protein, and one truncating frameshift mutation (448 aa) has been linked to Tourette's syndrome, a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. In addition, all SLITRK genes are differentially expressed in brain tumors, such as astrocytoma, oligodendroglioma, glioblastoma, and are suggested to be useful molecular indicators of brain tumor properties.
Full Name
SLIT and NTRK like family member 1
References

    1. Aruga, J. and Mikoshiba, K. 2003, Mol. Cell. Neurosci. 24: 117-129.

    2. Aruga, J. et al., 2003, Gene. 315: 87-94.

    3. Abelson, J.F. et al., 2005, Science. 310: 317-320.

    4. Grados, M.A. and Walkup. J.T. 2006, Trends. Genet. 22: 291-293.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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