All Band 3 reagents are produced in house and quality controlled, including 2 Band 3 Antibody, 28 Band 3 Gene, 2 Band 3 qPCR. All Band 3 reagents are ready to use.
Band 3 antibodies are validated with different applications, which are IHC-P.
Band 3 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Band 3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The Band 3 (AE1, SLC4A1) membrane protein is found in red blood cells and in kidney where it functions as an electro-neutral chloride/bicarbonate exchanger. Primary distal renal tubular acidosis (dRTA) caused by mutations of the SLC4A1 gene, which encodes for erythroid and kidney isoforms of anion exchanger, shows marked difference in inheritance patterns and clinical features in different parts of the world. Distal renal tubular acidosis caused by missense mutations in kidney isoform of anion exchanger 1 (kAE1/SLC4A1), the basolateral membrane Cl(-)/HCO3(-) exchanger of renal alpha-intercalated cells, has been extensively investigated in heterologous expression systems.