All SLAMF8 reagents are produced in house and quality controlled, including 5 SLAMF8 Antibody, 26 SLAMF8 Gene, 1 SLAMF8 Lysate, 1 SLAMF8 Protein, 2 SLAMF8 qPCR. All SLAMF8 reagents are ready to use.
Recombinant SLAMF8 proteins are expressed by HEK293 Cells with fusion tags as C-His.
SLAMF8antibodies are validated with different applications, which are IHC-P, WB, ELISA.
SLAMF8cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each SLAMF8 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells.
Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.