Anti-SLAMF8 Antibody

Cat: 50623-RP02
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Anti-SLAMF8 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SLAMF8 Antibody
Validated applications
WB,ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse SLAMF8
Immunogen
Recombinant Mouse SLAMF8 protein (Catalog#50623-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse SLAMF8 (rMouse SLAMF8; Catalog#50623-M08H; NP_083360.2; Met 1-Asp 231). SLAMF8 specific IgG was purified by Mouse SLAMF8 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SLAMF8 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SLAMF8 Antibody (Rabbit Polyclonal antibody) Images
Mouse SLAMF8 Immunohistochemistry(IHC) 3182
Immunochemical staining of mouse SLAMF8 in mouse spleen with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Mouse SLAMF8 Western blot (WB) 13692

Anti-SLAMF8 rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:32 kDa

Observed band size:27 kDa

(We are unsure as to the identity of these extra bands.)

Anti-SLAMF8 Antibody Alternative Names
Anti-5830408F06Rik Antibody;Anti-Blame Antibody;Anti-SBBI42 Antibody
SLAMF8 Background Information

The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells.
Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I  membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

Full Name
SLAM family member 8
References
  • Kingsbury G.A., et al., 2001, J. Immunol. 166:5675-80.
  • Zhang Z., et al., 2004, Protein Sci. 13: 2819-24.
  • Veillette,A. et al., 2006, Nat Rev Immunol  6 (1): 56-66.
  • Veillette,A. et al., 2006, Trends Immunol  27 (5): 228-34.
  • Yan,Q. et al., 2007, Proc Natl Acad Sci. USA.104 (25):10583-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SLAMF8 Antibody Rabbit Monoclonal ELISA 50623-R210
    Anti-SLAMF8 Antibody Rabbit Monoclonal IHC-P 50623-R242
    Anti-SLAMF8 Antibody Rabbit Polyclonal WB,ELISA 50623-T48
    Anti-SLAMF8 Antibody Rabbit Polyclonal ELISA 50623-RP01
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