SIRT1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All SIRT1 reagents are produced in house and quality controlled, including 7 SIRT1 Antibody, 3 SIRT1 IPKit, 1 SIRT1 Protein. All SIRT1 reagents are ready to use.

Recombinant SIRT1 proteins are expressed by E. coli with fusion tags as N-His.

SIRT1 antibodies are validated with different applications, which are WB, IP, ELISA, ICC/IF, IF, IHC-P.

SIRT1 Protein (1)

Species

SIRT1 Protein, Human, Recombinant (His Tag)

11748-H07E

Expression host: E. coli

Human SIRT1 Protein 9816
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SIRT1 Antibody (7)

Application Clonality
Host

Anti-SIRT1 Antibody

11748-T36

Specificity: Human

Application: WB,IP

Clonality: PAb

Human SIRT1 Immunoprecipitation(IP) 6032

Anti-SIRT1 Antibody

100799-T36

Specificity: Human

Application: WB,IP

Clonality: PAb

Human SIRT1 Immunoprecipitation(IP) 5985

Anti-SIRT1 Antibody

11748-RP01

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-SIRT1 Antibody

11748-MM04

Specificity: Human

Application: ELISA,IHC-P,ICC/IF,IF

Clonality: MAb

Human SIRT1 Immunohistochemistry(IHC) 3603

Anti-SIRT1 Antibody

11748-R012

Specificity: Human

Application: ELISA

Clonality: MAb

Anti-SIRT1 Antibody

11748-R032

Specificity: Human

Application: ELISA

Clonality: MAb

Anti-SIRT1 Antibody

11748-T54

Specificity: Human

Application: WB,ELISA,ICC/IF,IF,IP

Clonality: PAb

Human SIRT1 Western blot (WB) 15269
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SIRT1 IP Kit (3)

SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. It deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. SIRT1 also deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. It is involved in HES1- and HEY2-mediated transcriptional repression. SIRT1 inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. It may serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal muscle cell differentiation. It also deacetylates 'Lys-16' of histone H4 (in vitro). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.
Protein
Antibody
IPKit
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