SIRPG / SIRP gamma / CD172g Protein

Cluster of Differentiation 172g

SIRPG / SIRP gamma / CD172g Products

SIRPG / SIRP gamma / CD172g Protein, Recombinant

Molecule	Species	Description	Cat. No
SIRPG/SIRP gamma/CD172g	Human	SIRPG/SIRP gamma/CD172g Protein, Recombinant	11828-H08H

SIRPG / SIRP gamma / CD172g Antibody

Molecule	Application	Description	Cat. No
Human SIRPG/SIRP gamma/CD172g	WB,Elisa	Mouse Monoclonal Antibody	11828-MM04
Human SIRPG/SIRP gamma/CD172g	WB,Elisa	Rabbit Polyclonal Antibody	11828-RP01
Human SIRPG/SIRP gamma/CD172g	WB,Elisa	Rabbit Polyclonal Antibody	11828-RP02

SIRPG / SIRP gamma / CD172g Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>SIRPG/SIRP gamma/CD172g

Immunology>>Cluster of Differentiation>>SIRPG/SIRP gamma/CD172g

SIRPG / SIRP gamma / CD172g Alternative Names

SIRPG, SIRP gamma, CD172g, RP11-77C3.2, FLJ42230, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1 [Homo sapiens]

SIRPG / SIRP gamma / CD172g Background

Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

SIRPG / SIRP gamma / CD172g Related Studies

1. Meador JA, et al. (2011) p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation. Radiat Res. 175(6): 689-99.
2. Reddy MV, et al. (2011) Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes Immun. 12(3): 208-12.
3. Kawasaki M, et al. (2009) Changes in the gene expression of peripheral blood mononuclear cells during the menstrual cycle of females is associated with a gender bias in the incidence of systemic lupus erythematosus. Clin Exp Rheumatol. 27(2): 260-6.