Anti-SIRP gamma Antibody

Cat: 11828-RP02
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Anti-SIRP gamma Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SIRP gamma Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human SIRP gamma
Immunogen
Recombinant Human SIRPG / SIRP gamma / CD172g protein (Catalog#11828-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human SIRPG / SIRP gamma / CD172g (rh SIRPG / SIRP gamma / CD172g; Catalog#11828-H08H; NP_061026.2; Met 1-Ser 364). SIRPG / SIRP gamma / CD172g specific IgG was purified by Human SIRPG / SIRP gamma / CD172g affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SIRP gamma Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SIRP gamma Antibody (Rabbit Polyclonal antibody) Images
Human SIRPG/SIRP gamma/CD172g Western blot (WB) 17398

Anti-SIRPG rabbit polyclonal antibody at 1:500 dilution.

Lane A: 293T Membrane Lysate

Lysates/proteins at 20 ug per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:42 kDa

Observed band size:33 kDa

(We are unsure as to the identity of these extra bands.)

Anti-SIRP gamma Antibody Alternative Names
Anti-bA77C3.1 Antibody;Anti-CD172g Antibody;Anti-SIRP-B2 Antibody;Anti-SIRPB2 Antibody;Anti-SIRPgamma Antibody
SIRP gamma Background Information

Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

Full Name
signal-regulatory protein gamma
References
  • Meador JA, et al. (2011) p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation. Radiat Res. 175(6): 689-99.
  • Reddy MV, et al. (2011) Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes Immun. 12(3): 208-12.
  • Kawasaki M, et al. (2009) Changes in the gene expression of peripheral blood mononuclear cells during the menstrual cycle of females is associated with a gender bias in the incidence of systemic lupus erythematosus. Clin Exp Rheumatol. 27(2): 260-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SIRP gamma Antibody Rabbit Polyclonal ELISA 11828-RP01
    Anti-SIRP gamma Antibody Mouse Monoclonal ELISA 11828-MM04
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