All SIRP-beta reagents are produced in house and quality controlled, including 3 SIRP-beta Antibody, 12 SIRP-beta Gene, 1 SIRP-beta Lysate, 1 SIRP-beta Protein, 1 SIRP-beta qPCR. All SIRP-beta reagents are ready to use.
Recombinant SIRP-beta proteins are expressed by HEK293 Cells with fusion tags as C-His.
SIRP-betaantibodies are validated with different applications, which are ELISA.
SIRP-betacDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each SIRP-beta of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing a 110- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.