SIRP-beta / Sirpb1a (Protein | Antibody | cDNA Clone | ELISA Kit)

All SIRP-beta / Sirpb1a reagents are produced in house and quality controlled, including 3 SIRP-beta / Sirpb1a Antibody, 12 SIRP-beta / Sirpb1a Gene, 1 SIRP-beta / Sirpb1a Lysate, 1 SIRP-beta / Sirpb1a Protein, 1 SIRP-beta / Sirpb1a qPCR. All SIRP-beta / Sirpb1a reagents are ready to use.

SIRP-beta / Sirpb1a Protein (1)

SIRP-beta / Sirpb1a Antibody (3)

SIRP-beta / Sirpb1a cDNA Clone (12)

SIRP-beta / Sirpb1a qPCR Primer (1)

SIRP-beta / Sirpb1a Lysate (1)

SIRP-beta / Sirpb1a Background

SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing a 11- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.

SIRP-beta / Sirpb1a References

  • Gaikwad S, et al. (2009) Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease. Am J Pathol. 175(6): 2528-39.
  • Dietrich J, et al. (2000) Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. J Immunol. 164(1): 9-12.
  • Tomasello E, et al. (2000) Association of signal-regulatory proteins beta with KARAP/DAP-12. Eur J Immunol. 30(8): 2147-56.