SIRPB1A / SIRP beta 1 Protein

Signal-regulatory protein beta 1A

SIRPB1A / SIRP beta 1 Products

SIRPB1A / SIRP beta 1 Protein, Recombinant

Molecule	Species	Description	Cat. No
SIRPB1A/SIRP beta 1	Mouse	SIRPB1A/SIRP beta 1 Protein, Recombinant	50816-M08H

SIRPB1A / SIRP beta 1 cDNA Clone

Molecule	Species	Description	Cat. No
SIRPB1A/SIRP beta 1	Mouse	Mouse SIRPB1A cDNA Clone / ORF Clone	MG50816-G

SIRPB1A / SIRP beta 1 Alternative Names

Sirpb1a, Sirpb, Sirpb1, SIRP-beta, 9930027N05Rik [Mus musculus]

SIRPB1A / SIRP beta 1 Background

SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing a 110- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.

SIRPB1A / SIRP beta 1 Related Studies

1. Gaikwad S, et al. (2009) Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease. Am J Pathol. 175(6): 2528-39.
2. Dietrich J, et al. (2000) Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. J Immunol. 164(1): 9-12.
3. Tomasello E, et al. (2000) Association of signal-regulatory proteins beta with KARAP/DAP-12. Eur J Immunol. 30(8): 2147-56.