Anti-SIRP alpha Antibody

Cat: 11612-RP01
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Anti-SIRP alpha Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SIRP alpha Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human SIRP alpha
Immunogen
Recombinant Human SIRPA protein (Catalog#11612-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human SIRPA (rh SIRPA; Catalog#11612-H08H; NP_542970.1; Met 1-Arg 370). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SIRP alpha Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SIRP alpha Antibody Alternative Names
Anti-BIT Antibody;Anti-CD172A Antibody;Anti-MFR Antibody;Anti-MYD-1 Antibody;Anti-P84 Antibody;Anti-PTPNS1 Antibody;Anti-SHPS1 Antibody;Anti-SIRP Antibody;Anti-SIRP alpha Antibody
SIRP alpha Background Information

Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
signal-regulatory protein alpha
References
  • Timms JF. et al., 1999, Curr Biol. 9: 927-30.
  • Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9.
  • Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
  • Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SIRP alpha Antibody (FITC) Rabbit Monoclonal FCM 80270-R103-F
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    Anti-SIRP alpha Antibody Rabbit Monoclonal FCM 50956-R012
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    Anti-SIRP alpha Antibody (FITC) Rabbit Monoclonal FCM 50956-R001-F
    Anti-SIRP alpha Antibody Rabbit Monoclonal ELISA,FCM 50956-R001
    Anti-SIRP alpha Antibody (APC) Rabbit Monoclonal FCM 50956-R001-A
    Anti-SIRP alpha Antibody (PE) Rabbit Monoclonal FCM 50956-R012-P
    Anti-SIRP alpha Antibody Rabbit Monoclonal ELISA 50956-R009
    Anti-SIRP alpha Antibody (FITC) Rabbit Monoclonal FCM 50956-R012-F
    Anti-SIRP alpha Antibody (APC) Mouse Monoclonal FCM 11612-MM03-A
    Anti-SIRP alpha Antibody Mouse Monoclonal ELISA,FCM 11612-MM03
    Anti-SIRP alpha Antibody (FITC) Mouse Monoclonal FCM 11612-MM03-F
    Anti-SIRP alpha Antibody (PE) Mouse Monoclonal FCM 11612-MM03-P
    Anti-SIRP alpha Antibody Rabbit Polyclonal ELISA,IP 11612-RP02
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