SIGNR1 / CD209b Protein & Antibody

DC-SIGN-related protein 1 / CD209 antigen-like protein B

SIGNR1 / CD209b Products

SIGNR1 / CD209b Protein, Recombinant

Molecule	Application	Description	Cat. No
Mouse SIGNR1/CD209b	WB, ELISA	SIGNR1 / CD209b Antibody	50486-RP01
Mouse SIGNR1/CD209b	WB, ELISA	SIGNR1 / CD209b Antibody (Antigen Affinity Purified)	50486-RP02

SIGNR1 / CD209b Antibody

Molecule	Species	Description	Cat. No
SIGNR1/CD209b	Mouse	Mus musculus SIGNR1/CD209b cDNA Clone	MG50486-M

SIGNR1 / CD209b cDNA Clone

Molecule	Species	Description	Cat. No
SIGNR1/CD209b	Mouse	Mus musculus SIGNR1/CD209b cDNA Clone	MG50486-M

SIGNR1 / CD209b Related Areas

Immunology>>Adhesion Molecule>>Lectin>>SIGNR1/CD209b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>SIGNR1/CD209b

SIGNR1 / CD209b Alternative Names

Cd209b, DC-SIGNR1, 1810030I22Rik, OtB7, SIGNR1, mSIGNR1 [Mus musculus]

SIGNR1 / CD209b Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD209b, also known as SIGNR1, is a C-type lectin receptor. CD209b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD209b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD209b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.

SIGNR1 / CD209b Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Park JY, et al. (2009) The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumonia. Neuroscience Letters. 450 (3): 246-51.