Anti-SIGNR1 Antibody

Cat: 50486-RP02
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Anti-SIGNR1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SIGNR1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse SIGNR1
Immunogen
Recombinant Mouse SIGNR1 / CD209b protein (Catalog#50486-M07H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse SIGNR1 / CD209b (rM SIGNR1 / CD209b; Catalog#50486-M07H; NP_081248.2; Gln 74-Gly 325). SIGNR1 / CD209b specific IgG was purified by Mouse SIGNR1 / CD209b affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SIGNR1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SIGNR1 Antibody Alternative Names
Anti-1810030I22Rik Antibody;Anti-DC-SIGNR1 Antibody;Anti-mSIGNR1 Antibody;Anti-OtB7 Antibody;Anti-SIGNR1 Antibody
SIGNR1 Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD209b, also known as SIGNR1, is a C-type lectin receptor. CD209b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD209b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD209b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.

Full Name
CD209b antigen
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Park JY, et al. (2009) The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumonia. Neuroscience Letters. 450 (3): 246-51.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SIGNR1 Antibody (PE) Rabbit Monoclonal FCM 50486-R143-P
    Anti-SIGNR1 Antibody Rabbit Polyclonal ELISA 50486-RP01
    Anti-SIGNR1 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50486-R143
    Anti-SIGNR1 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 50486-R001
    Anti-SIGNR1 Antibody Rabbit Monoclonal ELISA(Cap) 50486-R123
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