All SIGLEC6 reagents are produced in house and quality controlled, including 13 SIGLEC6 Gene, 1 SIGLEC6 Lysate, 1 SIGLEC6 Protein, 1 SIGLEC6 qPCR. All SIGLEC6 reagents are ready to use.
Recombinant SIGLEC6 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc.
SIGLEC6 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each SIGLEC6 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
SIGLEC6, also known as CD327, belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC6 is a sialic acid recognizing protein expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. SIGLEC6 localizes in various compartments such as membrane fraction, extracellular region and so on. SIGLEC6 may show increasing expression human labor and following childbirth, it has been speculated that this expression helps to slow the tempo of human labor. Interestingly, expression of SIGLEC6 is further upregulated in pre-eclampsia, which appears to be a uniquely human disease.
Winn VD. et al., 2009, Endocrinology. 150 (1): 452-62.
Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
Lam KK. et al., 2011, J Biol Chem. 286 (43): 37118-27.