All SIGLEC5 reagents are produced in house and quality controlled, including 11 SIGLEC5 Antibody, 1 SIGLEC5 ELISA, 12 SIGLEC5 Gene, 2 SIGLEC5 Lysate, 2 SIGLEC5 Protein, 1 SIGLEC5 qPCR. All SIGLEC5 reagents are ready to use.
Recombinant SIGLEC5 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-cleavage.
SIGLEC5antibodies are validated with different applications, which are ELISA(Cap), FCM, ELISA.
SIGLEC5cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each SIGLEC5 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
SIGLEC5ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
SIGLEC5 contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. It belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC5 is expressed by monocytic/myeloid lineage cells. It is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is also expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.