SIGIRR Protein (TIR8 Protein)

Single Immunoglobulin IL-1 Receptor-Related molecule (Toll-Interleukin 1 Receptor 8)

SIGIRR Products

SIGIRR Protein, Recombinant

Molecule	Species	Description	Cat. No
SIGIRR/TIR8	Human	SIGIRR/TIR8 Protein, Recombinant	12165-H08H
SIGIRR/TIR8	Mouse	SIGIRR/TIR8/Fc Protein, Recombinant	50122-M03H

SIGIRR Antibody

Molecule	Application	Description	Cat. No
Human SIGIRR/TIR8	WB, ELISA	SIGIRR / TIR8 Antibody	12165-RP01
Human SIGIRR/TIR8	WB, ELISA	SIGIRR / TIR8 Antibody (Antigen Affinity Purified)	12165-RP02

SIGIRR cDNA Clone Products

Molecule	Species	Description	Cat. No
SIGIRR/TIR8	Human	SIGIRR cDNA Clone / ORF Clone	HG12165-G
SIGIRR/TIR8	Mouse	Mus musculus SIGIRR/TIR8 cDNA Clone	MG50122-M

SIGIRR Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>SIGIRR/TIR8

SIGIRR Alternative Names

UNQ301, PRO342, MGC110992, TIR8 [Homo sapiens]

AI256711, MGC102426, TIR8 [Mus musculus]

SIGIRR Background

Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.

SIGIRR Related Studies

1. Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9): 920-7.
2. Polentarutti N, et al. (2003) Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw. 14(4): 211-8.
3. Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9): 920-7.