Anti-SIGIRR Antibody

Cat: 12165-RP01
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Anti-SIGIRR Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SIGIRR Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human SIGIRR
Immunogen
Recombinant Human SIGIRR protein (Catalog#12165-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human SIGIRR (rh SIGIRR; Catalog#12165-H08H; Met 1-His 118; Q6IA17-1). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SIGIRR Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SIGIRR Antibody Alternative Names
Anti-TIR8 Antibody
SIGIRR Background Information

Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.

Full Name
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
References
  • Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9): 920-7.
  • Polentarutti N, et al. (2003) Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw. 14(4): 211-8.
  • Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9): 920-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SIGIRR Antibody Rabbit Polyclonal IHC-P 106749-T08
    Anti-SIGIRR Antibody (PE) Rabbit Monoclonal FCM 12165-R010-P
    Anti-SIGIRR Antibody Rabbit Monoclonal ELISA 12165-R016
    Anti-SIGIRR Antibody Rabbit Polyclonal ELISA 12165-RP02
    Anti-SIGIRR Antibody Rabbit Monoclonal FCM 12165-R010
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