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SHP2 / PTPN11

SHP2 / PTPN11 Protein & Antibody

Entrez Gene Summary for SHP2 / PTPN11


The protein encoded by this PTPN11 gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This SHP2 protein contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This SHP2 protein is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

OMIM-Description for SHP2 / PTPN11


The protein-tyrosine phosphatases are a highly pleomorphic set of molecules that have a role in regulating the responses of eukaryotic cells to extracellular signals (Dechert et al., 1995). They achieve this by regulating the phosphotyrosine content of specific intracellular proteins. The PTPases have been grouped by virtue of the characteristic catalytic domain sequence similarities that define this family. Dechert et al. (1995) noted that the noncatalytic domain shows a striking degree of sequence heterogeneity. In general, however, mammalian PTPases can be subdivided into 1 of 2 broad categories: (1) transmembrane receptor PTPases that contain linked cytoplasmic catalytic domains, and (2) intracellular PTPases. Included within the latter category are 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. SH2 domains enable the binding of these SH2 domain-containing PTPases to specific phosphotyrosine residues within protein sequences. The first mammalian SH2 domain-containing PTPase identified was PTP1C (PTPN6; 176883). The second mammalian SH2 domain-containing PTPase identified is encoded by the PTPN11 gene.

.zh=SHP2 / PTPN11


Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D) or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

SHP2 / PTPN11 Alternative Names

CFC,NS1,SHP2,BPTP3,PTP2C,PTP-1D,SH-PTP2,SH-PTP3, [homo-sapiens]
BPTP3,CFC,NS1,protein-tyrosine phosphatase 1D,protein-tyrosine phosphatase 2C,PTP-1D,PTP2C,PTP-2C,SHP2,SH-PTP2,SH-PTP3,tyrosine-protein phosphatase non-receptor type 11, [human]
2700084A17Rik,AW536184,protein-tyrosine phosphatase SYP,PTP1D,PTP2C,SAP-2,SH2 domain-containing protein tyrosine phosphatase-2,Shp2,SHP-2,SH-PTP2,SH-PTP3,Syp,tyrosine-protein phosphatase non-receptor type 11, [mouse]
Sap-2,Syp,Shp2,PTP1D,PTP2C,SHP-2,SH-PTP2,SH-PTP3,AW536184,2700084A17Rik, [mus-musculus]

SHP2 / PTPN11 Related Products

SHP2 / PTPN11 Proteins

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Mouse SHP2 / PTPN11 Protein (His Tag)

SHP2 / PTPN11 Antibodies

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SHP2 / PTPN11 cDNA Clones

Product nameProduct name
Mouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, N-HA tagHuman PTPN11 ORF mammalian expression plasmid, N-Myc tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, C-HA tagHuman PTPN11 ORF mammalian expression plasmid, N-His tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, C-His tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, N-Flag tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, N-GFPSpark tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, C-Flag tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, C-Myc tagHuman PTPN11 ORF mammalian expression plasmid, C-Myc tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, C-GFPSpark tagMouse PTPN11 transcript variant 2 natural ORF mammalian expression plasmidHuman PTPN11 ORF mammalian expression plasmid, C-OFPSpark / RFP tagHuman PTPN11 ORF mammalian expression plasmid, N-OFPSpark / RFP tagHuman PTPN11 ORF mammalian expression plasmid, N-HA tagHuman PTPN11 ORF mammalian expression plasmid, C-HA tagHuman PTPN11 ORF mammalian expression plasmid, C-GFPSpark tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, N-Myc tagHuman PTPN11 ORF mammalian expression plasmid, C-His tagHuman PTPN11 ORF mammalian expression plasmid, N-GFPSpark tagMouse PTPN11 transcript variant 2 Gene cDNA clone plasmidHuman PTPN11 ORF mammalian expression plasmid, N-Flag tagHuman PTPN11 Gene cDNA clone plasmidHuman PTPN11 natural ORF mammalian expression plasmidMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, N-His tagHuman PTPN11 ORF mammalian expression plasmid, C-Flag tagMouse PTPN11 transcript variant 2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag

SHP2 / PTPN11 ELISA

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