Anti-SAP Antibody

Cat: 11149-T16
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Anti-SAP Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SAP Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human SAP
Immunogen
Recombinant Human SH2D1A protein (Catalog#11149-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human SH2D1A (rh SH2D1A; Catalog#11149-H07E; NP_002342.1; Pro2-Lys97). SH2D1A specific IgG was purified by Human SH2D1A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SAP Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SAP Antibody Alternative Names
Anti-DSHP Antibody;Anti-EBVS Antibody;Anti-IMD5 Antibody;Anti-LYP Antibody;Anti-MTCP1 Antibody;Anti-SAP Antibody;Anti-SAP/SH2D1A Antibody;Anti-XLP Antibody;Anti-XLPD Antibody;Anti-XLPD1 Antibody
SAP Background Information

SH2 domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD150 / SLAM, CD84, CD229 / Ly-9, and CD244 / 2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome. 

Full Name
SH2 domain containing 1A
References
  • Morra M, et al. (2005) Defective B cell responses in the absence of SH2D1A. PNAS. 102 (13): 4819-23.
  • Morra M, et al. (2001) Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients. The Journal of Biological Chemistry. 276: 36809-16.
  • Hron JD, et al. (2004) SH2D1A Regulates T-dependent Humoral Autoimmunity. JEM. 200 (2): 261-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SAP Antibody Rabbit Polyclonal ELISA 11149-RP01
    Anti-SAP Antibody Rabbit Monoclonal ELISA 11149-R028
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