SFTPD Protein & Antibody (SP-D, SFTP4)

Surfactant associated protein D

SFTPD Products

SFTPD Protein, Recombinant

Molecule	Species	Description	Cat. No
SFTPD/SP-D/SFTP4	Human	SFTPD Protein, Recombinant	11041-H08H
SFTPD/SP-D/SFTP4	Mouse	SFTPD Protein, Recombinant	50205-M08H
SFTPD/SP-D/SFTP4	Cynomolgus	SFTPD Protein, Recombinant	90003-C08H

SFTPD Antibody

Molecule	Application	Description	Cat. No
Mouse SFTPD/SP-D/SFTP4	ELISA	SFTPD/SP-D/SFTP4 Antibody, Rabbit MAb	50205-R019
Mouse SFTPD/SP-D/SFTP4	WB, ELISA	Rabbit Polyclonal Antibody	50205-RP01
Mouse SFTPD/SP-D/SFTP4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50205-RP02
Cynomolgus SFTPD/SP-D/SFTP4	WB, ELISA	SFTPD / SP-D / SFTP4 Antibody	90003-RP01
Cynomolgus SFTPD/SP-D/SFTP4	WB, ELISA	SFTPD / SP-D / SFTP4 Antibody (Antigen Affinity Purified)	90003-RP02

SFTPD cDNA Clone

Molecule	Species	Description	Cat. No
SFTPD/SP-D/SFTP4	Human	Homo sapiens SFTPD cDNA Clone(NM_003019.4)	HG11041-M
SFTPD/SP-D/SFTP4	Mouse	Mus musculus SFTPD cDNA Clone	MG50205-M
SFTPD/SP-D/SFTP4	Rat	SFTPD cDNA Clone / ORF Clone	RG80256-G
SFTPD/SP-D/SFTP4	Cynomolgus	SFTPD cDNA Clone / ORF Clone	KG90003-G

SFTPD Related Areas

Immunology>>Adhesion Molecule>>Lectin>>SFTPD/SP-D/SFTP4

Immunology>>Innate Immunity>>Acute Phase Proteins>>SFTPD/SP-D/SFTP4

SFTPD Alternative Names

SFTPD, SP-D, SFTP4, COLEC7, PSP-D [Homo sapiens]

SFTPD, SP-D, Sftp4, AI573415 [Mus musculus]

SFTPD Background

Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia, asthma, and bleomycin injury. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.

SFTPD Related Studies

1. Leth-Larsen R, et al. (2005) A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D. J Immunol. 174(3): 1532-8.
2. Moran AP, et al. (2005) Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide. J Endotoxin Res. 11(6): 357-62.
3. Hartl D, et al. (2006) Surfactant protein D in human lung diseases. Eur J Clin Invest. 36(6): 423-35.
4. Krueger M, et al. (2006) Amino acid variants in Surfactant protein D are not associated with bronchial asthma. Pediatr Allergy Immunol. 17(1): 77-81.
5. Glas J, et al. (2008) Increased plasma concentration of surfactant protein D in chronic periodontitis independent of SFTPD genotype: potential role as a biomarker. Tissue Antigens. 72(1): 21-8.