Quick Order

SFTPD / SP-D / SFTP4 Antibody, Rabbit PAb, Antigen Affinity Purified

DatasheetReviewsRelated ProductsProtocols
Mouse SFTPD Antibody Product Information
Immunogen:Recombinant Mouse SFTPD protein (Catalog#50205-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse SFTPD (rM SFTPD; Catalog#50205-M08H; NP_033186.1; Met 1-Phe 374). SFTPD specific IgG was purified by mouse SFTPD affinity chromatography.
Mouse SFTPD Antibody Usage Guide
Specificity:Mouse SFTPD / PSPD / COLEC7
Application:ELISA, IHC-P

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse SFTPD. The detection limit for Mouse SFTPD is 0.00245 ng/well.

IHC-P: 0.1-2 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse SFTPD Antibody IHC Application Image
SFTPD / SP-D / SFTP4 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse SFTPD in mouse lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other SFTPD Antibody Products
Reactivity: Mouse  
Application: ELISA  
    50205-RP01-400
    50205-RP01-100
    50205-RP01-200
     
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  
      50205-R019-50
      50205-R019-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: IHC-P  
      • Slide 1
      50205-R119-100
      50205-R119-50
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Cynomolgus  
      Application: ELISA  
        90003-R111-50
        90003-R111-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Cynomolgus  
        Application: ELISA  
          90003-RP01-100
          90003-RP01-200
          90003-RP01-400
          100 µg 
          200 µg 
           
          Add to Cart
          Reactivity: Cynomolgus  
          Application: ELISA  
            90003-RP02-50
            90003-RP02-100
            90003-RP02-200
            50 µg 
            100 µg 
            200 µg 
            Add to Cart
            Reactivity: Rhesus  
            Application: IHC-P  
            • Slide 1
            90003-R001-100
            90003-R001-50
            100 µg 
            50 µg 
            Add to Cart
            SFTPD/SP-D Background

            Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia and asthma. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.

            Mouse SFTPD/SP-D References
          • Leth-Larsen R, et al. (2005) A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D. J Immunol. 174(3): 1532-8.
          • Moran AP, et al. (2005) Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide. J Endotoxin Res. 11(6): 357-62.
          • Hartl D, et al. (2006) Surfactant protein D in human lung diseases. Eur J Clin Invest. 36(6): 423-35.
          • Krueger M, et al. (2006) Amino acid variants in Surfactant protein D are not associated with bronchial asthma. Pediatr Allergy Immunol. 17(1): 77-81.
          • Glas J, et al. (2008) Increased plasma concentration of surfactant protein D in chronic periodontitis independent of SFTPD genotype: potential role as a biomarker. Tissue Antigens. 72(1): 21-8.
          • Product nameProduct name
            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"