Quick Order

SFTPD / SP-D / SFTP4 Antibody, Rabbit PAb

DatasheetReviewsRelated ProductsProtocols
Mouse SFTPD Antibody Product Information
Immunogen:Recombinant Mouse SFTPD protein (Catalog#50205-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse SFTPD (rM SFTPD; Catalog#50205-M08H; NP_033186.1; Met 1-Phe 374). Total IgG was purified by Protein A affinity chromatography.
Mouse SFTPD Antibody Usage Guide
Specificity:Mouse SFTPD / PSPD / COLEC7
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse SFTPD. The detection limit for Mouse SFTPD is 0.039 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other SFTPD Antibody Products
Reactivity: Mouse  
Application: ELISA  IHC-P  
  • Slide 1
50205-RP02-200
50205-RP02-50
50205-RP02-100
200 µg 
50 µg 
100 µg 
Add to Cart
Reactivity: Mouse  
Application: ELISA  
    50205-R019-50
    50205-R019-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Mouse  
    Application: IHC-P  
    • Slide 1
    50205-R119-100
    50205-R119-50
    100 µg 
    50 µg 
    Add to Cart
    Reactivity: Cynomolgus  
    Application: ELISA  
      90003-R111-50
      90003-R111-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Cynomolgus  
      Application: ELISA  
        90003-RP01-100
        90003-RP01-200
        90003-RP01-400
        100 µg 
        200 µg 
         
        Add to Cart
        Reactivity: Cynomolgus  
        Application: ELISA  
          90003-RP02-50
          90003-RP02-100
          90003-RP02-200
          50 µg 
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Rhesus  
          Application: IHC-P  
          • Slide 1
          90003-R001-100
          90003-R001-50
          100 µg 
          50 µg 
          Add to Cart
          SFTPD/SP-D Background

          Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia and asthma. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.

          Mouse SFTPD/SP-D References
        • Leth-Larsen R, et al. (2005) A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D. J Immunol. 174(3): 1532-8.
        • Moran AP, et al. (2005) Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide. J Endotoxin Res. 11(6): 357-62.
        • Hartl D, et al. (2006) Surfactant protein D in human lung diseases. Eur J Clin Invest. 36(6): 423-35.
        • Krueger M, et al. (2006) Amino acid variants in Surfactant protein D are not associated with bronchial asthma. Pediatr Allergy Immunol. 17(1): 77-81.
        • Glas J, et al. (2008) Increased plasma concentration of surfactant protein D in chronic periodontitis independent of SFTPD genotype: potential role as a biomarker. Tissue Antigens. 72(1): 21-8.
        • Product nameProduct name
          Size / Price
          Catalog: 50205-RP01-400
          List Price: 
          Price:      (You Save: )
          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"