Anti-Surfactant protein D Antibody

Cat: 50205-RP01
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Anti-Surfactant protein D Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Surfactant protein D Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Surfactant protein D
Immunogen
Recombinant Mouse SFTPD protein (Catalog#50205-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse SFTPD (rM SFTPD; Catalog#50205-M08H; NP_033186.1; Met 1-Phe 374). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Surfactant protein D Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Surfactant protein D Antibody Alternative Names
Anti-AI573415 Antibody;Anti-Sftp4 Antibody;Anti-SP-D Antibody
Surfactant protein D Background Information

Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. The polymorphic variation in the N-terminal domain of the SP-D molecule influences oligomerization, function, and the concentration of the molecule in serum. SFTPD is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia and asthma. SFTPD is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Thus, recombinant SFTPD has been proposed as a therapeutical option for cystic fibrosis, neonatal lung disease and smoking-induced emphysema. Furthermore, SFTPD serum levels can be used as disease activity markers for interstitial lung diseases.

Full Name
surfactant protein D
References
  • Leth-Larsen R, et al. (2005) A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D. J Immunol. 174(3): 1532-8.
  • Moran AP, et al. (2005) Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide. J Endotoxin Res. 11(6): 357-62.
  • Hartl D, et al. (2006) Surfactant protein D in human lung diseases. Eur J Clin Invest. 36(6): 423-35.
  • Krueger M, et al. (2006) Amino acid variants in Surfactant protein D are not associated with bronchial asthma. Pediatr Allergy Immunol. 17(1): 77-81.
  • Glas J, et al. (2008) Increased plasma concentration of surfactant protein D in chronic periodontitis independent of SFTPD genotype: potential role as a biomarker. Tissue Antigens. 72(1): 21-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Surfactant protein D Antibody Rabbit Monoclonal IHC-P 90003-R001
    Anti-Surfactant protein D Antibody Rabbit Polyclonal ELISA 90003-RP01
    Anti-Surfactant protein D Antibody Rabbit Polyclonal ELISA 90003-RP02
    Anti-Surfactant protein D Antibody Rabbit Monoclonal ELISA 90003-R111
    Anti-Surfactant protein D Antibody Rabbit Monoclonal IHC-P 50205-R119
    Anti-Surfactant protein D Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 50205-R019
    Anti-Surfactant protein D Antibody Rabbit Polyclonal ELISA,IHC-P 50205-RP02
    Anti-Surfactant protein D Antibody Rabbit Polyclonal ELISA 11041-T16
    Anti-Surfactant protein D Antibody Rabbit Polyclonal ELISA 11041-RP01
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