SFRP4

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. SFRP4 increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling By similarity. SFRP4 has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.

SFRP4 Related Areas

Signal Transduction>>Wnt Signaling Pathway>>Wnt Inhibitor>>SFRP4

Stem Cell>>Wnt Signaling Pathway>>Wnt Inhibitor>>SFRP4

SFRP4 Alternative Names

SFRP4, FRP-4, FRPHE, MGC26498

Summaries for SFRP4

Entrez Gene summary for SFRP4:

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

Wikipedia summary for SFRP4:

Secreted frizzled-related protein 4 is a protein that in humans is encoded by the SFRP4 gene.
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.

Human SFRP4 Protein General Information

 

• Protein names: Secreted frizzled-related protein 4
  Short name=sFRP-4
• Sequence length: 346 AA.
• Domain: The FZ domain is involved in binding with Wnt ligands
• Sequence similarities: Belongs to the secreted frizzled-related protein (sFRP) family.
  Contains 1 FZ (frizzled) domain.
  Contains 1 NTR domain.
• Induction: Increased levels in failing myocardium. Up-regulated in several tumor types including ostomalacia-associated tumors and endometrial and breast carcinomas.
• Sequence caution: The sequence BAG63683.1 differs from that shown. Reason: Erroneous initiation.
• Subcellular location: Secreted. Note: Cytoplasmic in ovarian tumor cells.
• Tissue specificity: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).

General information above from UniProt

Function for SFRP4 Protein

UniProtKB:

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. SFRP4 increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling By similarity. SFRP4 has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.

Genatlas:

• SFRP4 plays a potential role in the pathogenesis of ADPKD (Romaker 2009)
• SFRP4 is likely involved in WNT binding, and acting as soluble modulators of Wnt signaling
• SFRP4 promotes epidermal differentiation (Maganga 2008)
• SFRP4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells (Berndt 2006)

Homology for human SFRP4

• homolog to Drosophila frizzled polarity
• homolog to murine Sfrp 4