SFRP2

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

SFRP2 Related Areas

Signal Transduction>>Wnt Signaling Pathway>>Wnt Inhibitor>>SFRP2

Stem Cell>>Wnt Signaling Pathway>>Wnt Inhibitor>>SFRP2

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>SFRP2

SFRP2 Alternative Names

SFRP2, SDF-5, FRP-2, SARP1 [Homo sapiens]

Sfrp2, Sdf5, AI851596 [Mus musculus]

Summaries for SFRP2

Entrez Gene summary for SFRP2:

SFRP2 gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of SFRP2 gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]

Wikipedia summary for SFRP2:

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.

Human SFRP2 Protein General Information

 

• Protein names: Secreted frizzled-related protein 2
  Short name=FRP-2
  Short name=sFRP-2
• Sequence length: 295 AA.
• Domain: The FZ domain is involved in binding with Wnt ligands
• Sequence similarities: Belongs to the secreted frizzled-related protein (sFRP) family.
  Contains 1 FZ (frizzled) domain.
  Contains 1 NTR domain.
• Subcellular location: Secreted
• Tissue specificity: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.

General information above from UniProt

Function for SFRP2 Protein

UniProtKB:

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Genatlas:

• SFRP2 is likely involved in WNT binding
• WNT-frizzled proteins signaling pathways
• SFRP2 may regulate hematopoietic stem cells
• SFRP2 is involved in embryonic development as well as pathological conditions including bone and myocardial disorders and cancer
• SFRP2 has role as an enhancer of Wnt/beta-catenin signaling, a result with biological impact for both normal development and diverse pathologies such as tumorigenesis
• SFRP2 augments canonical Wnt3a/beta-catenin signaling at the level of its cell surface receptor
• SFRP2 is potential enhancer of canonical Wnt signaling and therefore has a possible role as a paracrine/autocrine positive modulator of this key cellular signal transduction pathway

Homology for human SFRP2

• homolog to Drosophila frizzled polarity
• homolog to murine Sfrp 2