SETD7 (SET7/9)

SETD7 is histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. SETD7 is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. SETD7 monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. SETD7 monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

SETD7 (SET7/9) Related Areas

Enzyme>>Methyltransferase>>SETD7 / SET7/9 / KMT7

SETD7 (SET7/9) Alternative Names

SETD7, SET7/9, KMT7, SET7, SET9, FLJ21193, KIAA1717 [Homo sapiens]

Setd7, Set7/9, 1600028F23Rik, KMT7, Set7, H3K4MT, mKIAA1717 [Mus musculus]

Summaries for SETD7 (SET7/9)

Wikipedia summary for SETD7 (SET7/9):

Histone-lysine N-methyltransferase SETD7 is an enzyme that in humans is encoded by the SETD7 gene.

Human SETD7 (SET7/9) Protein General Information

 

• Protein names: Histone-lysine N-methyltransferase SETD7
  Short name=SETD7
• Sequence length: 366 AA.
• Domain: The SET domain is necessary but not sufficient for histone methyltransferase activity.
• Sequence similarities: Belongs to the histone-lysine methyltransferase family. SET7 subfamily.
  Contains 3 MORN repeats.
  Contains 1 SET domain.
• Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
• Subunit structure: Interacts with IPF1/PDX-1.
• Subcellular location: Nucleus. Chromosome
• Tissue specificity: Widely expressed. Expressed in pancreatic islets.
• Miscellaneous: Monomethyltransferase activity is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction.
• Biophysicochemical properties: Kinetic parameters:
  K_M=29 µM for histone H3
  K_M=12 µM for TAF10
  K_M=69 µM for p53/TP53
• Sequence caution: The sequence BAB21808.1 differs from that shown. Reason: Erroneous initiation.

General information above from UniProt

Function for SETD7 (SET7/9) Protein

UniProtKB:

SETD7 is histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. SETD7 is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. SETD7 monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. SETD7 monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Genatlas:

• SETD7 methylates Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation
• SETD7 controls the opening or closing of chromatin
• SETD7 is required for heterochromatin formation
• SETD7 potentiates transcription activation
• SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin
• Set9 specifically methylates p53 at lys372 within the C-terminal regulatory region
• Set9 may be regulate function of non-histone proteins which plays a role of transcription activation
• Set9 functions as a transcriptional regulator through lysine methylation for p53, TAF10 and Estrogen receptor alpha
• Set9 methylates p300/CBP-associated factor (PCAF) at multiple lysine residues
• SETD7 catalyzes the site-specific methylation of protein lysyl residues in a host of proteins, including histones, transcription factors, chromatin-modifying enzymes, ribosomal subunits, and other substrates

Homology for human SETD7 (SET7/9)

• ortholog to setd7, Danio rerio
• ortholog to Setd7, Mus musculus
• ortholog to Setd7, Rattus norvegicus
• ortholog to SETD7, Pan troglodytes