Anti-SETD7 Antibody

Cat: 11209-MM05

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Anti-SETD7 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-SETD7 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human SETD7
Immunogen
Recombinant Human SETD7 protein (Catalog#11209-H07E)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SETD7 (rh SETD7; Catalog#11209-H07E; NP_085151.1; Asp 2-Lys 366). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #7H4C4F6
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SETD7 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 0.5-1 μg/mL  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SETD7 Antibody Alternative Names
Anti-KMT7 Antibody;Anti-SET7 Antibody;Anti-SET7/9 Antibody;Anti-SET9 Antibody
SETD7 Background Information

Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysine methyltransferase (PKMT), SETD7 also has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding in substrate proteins. The mono-methyltransferase activity of SETD7 is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction. SETD7 is also a novel coactivator of NF-kappaB and plays a role in inflammation and diabetes.

Full Name
SET domain containing (lysine methyltransferase) 7
References
  • Wang, H. et al., 2002, Mol Cell 8 (6): 1207-17. 
  • Jacobs, SA. et al., 2002, Nat. Struct. Biol. 9 (11): 833-8. 
  • Xiao B, et al., 2003, Nature. 421 (6923): 652-6.
  • Martens, JH. et al., 2003, Mol. Cell. Biol. 23: 1808-1816.
  • Couture, JF. et al., 2006, Nat Struct Mol Biol  13 (2): 140-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SETD7 Antibody Rabbit Polyclonal WB,ELISA,IP 11209-T52
    Anti-SETD7 Antibody Rabbit Polyclonal ELISA 11209-RP01
    Anti-SETD7 Antibody Mouse Monoclonal WB 11209-MM19
    Anti-SETD7 Antibody Rabbit Monoclonal ELISA 11209-R001
    Anti-SETD7 Antibody Mouse Monoclonal ELISA 11209-MM20
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