SerpinB3 cDNA ORF Clone in Cloning Vector, Human

Cat: HG13218-G
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SerpinB3 cDNA ORF Clone in Cloning Vector, Human General Information
NCBI Ref Seq
RefSeq ORF Size
1173 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutation 1069 A/G resulting in the amino acid Thr substitution by Ala.
Full length Clone DNA of Human serpin peptidase inhibitor, clade B (ovalbumin), member 3.
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
SerpinB3 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

SerpinB3 cDNA ORF Clone in Cloning Vector, Human Alternative Names
HsT1196 cDNA ORF Clone, Human;SCC cDNA ORF Clone, Human;SCCA-1 cDNA ORF Clone, Human;SCCA-PD cDNA ORF Clone, Human;SCCA1 cDNA ORF Clone, Human;T4-A cDNA ORF Clone, Human
SerpinB3 Background Information

SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.

Full Name
serpin peptidase inhibitor, clade B (ovalbumin), member 3
  • Schneider SS, et al. (1995) A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci. 92(8):3147-51.
  • Suminami Y, et al.. (1992) Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. Biochem Biophys Res Commun. 181(1):51-8.
  • Mino-Miyagawa N, et al. (1990) Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus. Cancer. 66(7):1505-12.
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