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Rat Semaphorin 4D / SEMA4D / CD100 Protein (His Tag)
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Rat Semaphorin 4D / SEMA4D / CD100 Protein (His Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80320-R08H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Protein Datasheet

 

 

SEMA4D / Semaphorin-4D Protein Price Inquiry ( Available Sizes )

SEMA4D / Semaphorin-4D Protein Product Information

Synonym : SEMA4D
Protein Construction:

A DNA sequence encoding the rat SEMA4D (Met1-Met712) was expressed, fused with a polyhistidine tag at the C-terminus.

Source: Rat
Expression Host: Human Cells

SEMA4D / Semaphorin-4D Protein QC Testing

Purity: > 95 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

SEMA4D / Semaphorin-4D protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Phe 24
Molecular Mass:

The recombinant rat SEMA4D comprises 700 amino acids and predicts a molecular mass of 77.8 kDa. The apparent molecular mass of  the recombinant protein is approximately 96 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

SEMA4D / Semaphorin-4D Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SEMA4D / Semaphorin-4D Protein Related Products & Topics

Related Areas:

Neuroscience>>Axon Guidance>>Semaphorin & Related Molecules>>Semaphorin 4D/SEMA4D/CD100

Immunology>>Cluster of Differentiation>>Semaphorin 4D/SEMA4D/CD100

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Syndecan-1/SDC1/CD138 Human Syndecan-1/SDC1/CD138 Protein, Recombinant 11429-H08H
Syndecan-1/SDC1/CD138 Mouse Syndecan-1/SDC1/CD138 Protein, Recombinant 50641-M08H
Syndecan-1/SDC1 Rat SDC1 / Syndecan-1 / SYND1 Protein, Recombinant 80344-R02H
Syndecan-1/SDC1 Rat SDC1 / Syndecan-1 / SYND1 Protein, Recombinant 80344-R08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human Semaphorin 4D/SEMA4D/CD100 WB, ELISA SEMA4D / CD100 Antibody 11825-MM02
Human Semaphorin 4D/SEMA4D/CD100 ELISA SEMA4D / CD100 Antibody 11825-MM06
Human Semaphorin 4D/SEMA4D/CD100 WB, ELISA SEMA4D / CD100 Antibody 11825-RP01
Human Semaphorin 4D/SEMA4D/CD100 WB, ELISA SEMA4D / CD100 Antibody (Antigen Affinity Purified) 11825-RP02
Mouse Semaphorin 4D/SEMA4D/CD100 WB, ELISA Semaphorin 4D / SEMA4D / CD100 Antibody 50642-RP01
Mouse Semaphorin 4D/SEMA4D/CD100 WB, ELISA Semaphorin 4D / SEMA4D / CD100 Antibody (Antigen Affinity Purified) 50642-RP02

SEMA4D / Semaphorin-4D Protein Description

Semaphorin-4D, also known as SEMA4D and CD100, is a single-pass type I  membrane protein which belongs to the semaphorin family. Semaphorin-4D / SEMA4D contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one Sema domain. Semaphorin-4D / SEMA4D is strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. Semaphorin-4D / SEMA4D may play a functional role in the immune system, as well as in the nervous system. Induces B-cells to aggregate and improves their viability. Semaphorin-4D / SEMA4D is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin-B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, Semaphorin-4D / SEMA4D binds CD72 to activate B cells and dendritic cells. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

References

  1. Masuda,K. et al., 2004, Genes Cells. 9 (9):821-9.
  2. Duran-Struuck R. et al., 2007, Biol Blood Marrow Transplant. 13 (11): 1294-303.
  3. Taniguchi Y. et al., 2009, J Neurosci Res. 87 (13): 2833-41.
  4. Ch'ng E S. et al., 2010, Mol Cancer. 9 :251.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"