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CD62L / L-Selectin / SELL Antibody (FITC), Rabbit MAb

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Mouse CD62L/SELL Antibody Product Information
Immunogen:Recombinant Mouse SELL protein (Catalog#50045-M08H)
Clone ID:414
Ig Type:Rabbit IgG
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SELL / CD62L / L-selectin (rM SELL / CD62L / L-selectin; Catalog#50045-M08H; NP_035476.1; Met 1-Asn 332) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Mouse CD62L/SELL Antibody Usage Guide
Specificity:Mouse SELL / CD62L / L-selectin
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Mouse CD62L/SELL Antibody FC Application Image
CD62L / L-Selectin / SELL Antibody (FITC), Rabbit MAb, Flow cytometric
[Click to enlarge image]
Flow cytometric analysis of CD62L expression on spleen lymphocytes. BALB/c splenocytes were treated with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 (Cat. No. 553141) and stained with FITC-conjugated anti-Mouse CD62L(50045-R414-F). The histogram were derived from the gated events based on light scattering characteristics of lymphocytes.
Other CD62L/SELL Antibody Products
CD62L/L-Selectin Background

L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

Mouse CD62L/L-Selectin References
  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.
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    Catalog: 50045-R414-F-50
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    50 Tests
    100 Tests
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