SECTM1 Protein & Antibody

Secreted and transmembrane

SECTM1 Products

SECTM1 Protein, Recombinant

Molecule	Species	Description	Cat. No
SECTM1	Human	SECTM /K12 Protein, Recombinant	12269-H08H

SECTM1 Antibody

Molecule	Application	Description	Cat. No
Human SECTM1	WB,Elisa	Mouse Monoclonal Antibody	12269-MM01
Human SECTM1	WB,Elisa	Rabbit Polyclonal Antibody (Antigen Purified)	12269-RP02

SECTM1 Antibody

Molecule	Species	Description	Cat. No
SECTM1	Human	SECTM1 cDNA Clone / ORF Clone	HG12269-G

SECTM1 Alternative Names

SECTM1, K12 [Homo sapiens]

Sectm1, Sectm1b, RP23-400P17.3, 1810003C24Rik, K12 [Mus musculus]

SECTM1 Background

Secreted and transmembrane 1 (SECTM1), also known as K12, is a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein of SECTM family. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. The human K12 protein has been shown to be primarily expressed in spleen, prostate, testis, small intestine, and in peripheral blood leukocytes. The K12 protein is expressed on the cell surface in such small amounts as to preclude detection. Alternatively, it may be that K12 on the cell surface is rapidly cleaved to generate a soluble K12 protein. Immunohistochemical analysis of peripheral blood cells shows that K12 is found in leukocytes of the myeloid lineage, with the strongest staining observed in granulocytes and no detectable expression in lymphocytes. May be involved in thymocyte signaling. It had been suggested a role for thymic microenvironment-produced K12 in regulation of thymocyte signaling and cytokine release, particularly in the setting of thymus pathology where IFN-gamma is upregulated such as myasthenia gravis. In addition, as a putative natural CD7 ligand, SECTM1/K12 may be responsible for the costimulatory role it plays in T cell activation.

SECTM1 Related Studies

1. Leta E, et al. (1995) Production and characterization of the extracellular domain of human CD7 antigen: further evidence that CD7 has a role in T cell signaling. Cell Immunol. 165(1): 101-9.
2. Slentz-Kesler KA, et al. (1998) Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. Genomics. 47(3): 327-40.
3. Lyman SD, et al. (2000) Identification of CD7 as a cognate of the human K12 (SECTM1) protein. J Biol Chem. 275(5): 3431-7.
4. Lam GK, et al. (2005) Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma. J Clin Immunol. 25(1): 41-9.