SCN2B

SCN2B plays a key role in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. Voltage-gated sodium channels (NaV) are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. Alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.They are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. SCN2B causes an increase in the plasma membrane surface area and in its folding into microvilli. SCN2B also interacts with TNR and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier.

SCN2B Related Areas

 

SCN2B Alternative Names

UNQ326/PRO386, neuronal voltage-gated sodium channel beta 2 subunit, sodium channel beta 2 subunit, sodium channel subunit beta-2, sodium channel, voltage-gated, type II, beta polypeptide [Homo sapiens]

2810451E09Rik, AI840361, Gm183, sodium channel subunit beta-2, sodium channel, voltage-gated, type II, beta polypeptide [Mus musculus]

Summaries for SCN2B

Wikipedia summary for SCN2B:

Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene.

Human SCN2B Protein General Information

 

• Protein names: Sodium channel subunit beta-2
• Sequence length: 215 AA.
• Sequence similarities: SCN2B belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family. [View classification]. SCN2B contains 1 Ig-like C2-type (immunoglobulin-like) domain.
• Subunit structure: The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR
• Subcellular location: Membrane; Single-pass type I membrane protein.
• Tissue specificity: Brain specific.

General information above from UniProt

Function for SCN2B Protein

UniProtKB:

SCN2B is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. SCN2B interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier

Genatlas:

• SCN2B is sodium channel, voltage-gated, type II, is involved in the initiation and conduction of electrical impulses in nerves

Homology for human SCN2B

• homolog to rattus contactin (with human auxilliary subunit beta)
• homolog to myelin protein zero, highly