Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.C
The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR (By similarity).
SCN2B is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli.
SCN2B is sodium channel, voltage-gated, type II, is involved in the initiation and conduction of electrical impulses in nerves