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Sodium channel, voltage-gated, type II, beta subunit Protein Datasheet
SCN2B Protein Price Inquiry ( Available Sizes )
SCN2B Protein Product Information
A DNA sequence encoding the human SCN2B (O60939) (Met1-Ala159) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
SCN2B Protein QC Testing
|Purity:||> 90 % as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met 30|
|Molecular Mass:||The recombinant human SCN2B /Fc is a disulfide-linked homodimer. The reduced monomer comprises 371 amino acids and has a predicted molecular mass of 42.2 kDa. The apparent molecular mass of the protein is approximately 53-57 kDa in SDS-PAGE under reducing conditions.|
|Formulation:||Lyophilized from sterile PBS, pH7.4.
SCN2B Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
SCN2B Protein Related Products & Topics
SCN2B Protein Description
SCN2B is essential for the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. Voltage-gated sodium channels (NaV) are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. Alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. They are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. SCN2B interacts with TNR and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier. SCN2B also causes an increase in the plasma membrane surface area and in its folding into microvilli.
- Tan BH. et al., 2010, Heart Rhythm. 7 (6): 771-8.
- Watanabe H. et al., 2009, Circ Arrhythm Electrophysiol. 2 (3): 268-75.