SCGN (Secretagogin)

 

SCGN (Secretagogin) Related Areas

Signal Transduction>>Calcium Signaling>>Calcium Binding Protein>>SCGN/Secretagogin

SCGN (Secretagogin) Alternative Names

SCGN, Secretagogin, CALBL, DJ501N12.8, SECRET, SEGN, setagin [Homo sapiens]

Scgn, Secretagogin, RP23-462P2.6, MGC27615 [Mus musculus]

Summaries for SCGN (Secretagogin)

Entrez Gene summary for SCGN (Secretagogin):

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]

Wikipedia summary for SCGN (Secretagogin):

Secretagogin is a protein that in humans is encoded by the SCGN gene.
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation.

Human SCGN (Secretagogin) Protein General Information

 

• Protein names: Secretagogin
  Short name=SCGN
• Sequence length: 276 AA.
• Domain: Repeat
• Sequence similarities: Contains 6 EF-hand domains.
• Subcellular location: Cytoplasm. Secreted . Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side . Note: Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions . Detectable in human serum after ischemic neuronal damage.
• Tissue specificity: Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons.

General information above from UniProt

Function for SCGN (Secretagogin) Protein

Genatlas:

• SCGN is calcium-binding protein
• SCGN may be involved in KCL-stimulated calcium flux and cell proliferation
• SCGN is novel marker for neuroendocrine differentiation.