SCGN (Secretagogin) Proteins
SCGN (Secretagogin) Antibodies
SCGN (Secretagogin) ELISA Pair sets
SCGN (Secretagogin) cDNA Clones
SCGN, Secretagogin, CALBL, DJ501N12.8, SECRET, SEGN, setagin [Homo sapiens]
Scgn, Secretagogin, RP23-462P2.6, MGC27615 [Mus musculus]
Entrez Gene summary for SCGN (Secretagogin):
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]
Wikipedia summary for SCGN (Secretagogin):
Secretagogin is a protein that in humans is encoded by the SCGN gene.
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation.
Contains 6 EF-hand domains.
|Subcellular location:||Cytoplasm. Secreted . Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side . Note: Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions . Detectable in human serum after ischemic neuronal damage.|
Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons.
General information above from UniProt
- SCGN is calcium-binding protein
- SCGN may be involved in KCL-stimulated calcium flux and cell proliferation
- SCGN is novel marker for neuroendocrine differentiation.