Anti-SCGN Antibody

Cat: 12411-MM06
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Anti-SCGN Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-SCGN Antibody
Validated applications
Species reactivity
Reacts with: Human
Human SCGN
Recombinant Human SCGN / Secretagogin protein (Catalog#12411-H07E)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SCGN / Secretagogin (rh SCGN / Secretagogin; Catalog#12411-H07E; NP_008929.2; Asp2-Pro276). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #06
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SCGN Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
IHC-P 1:50-1:200  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SCGN Antibody (Mouse Monoclonal antibody) Images
Human SCGN / Secretagogin Immunohistochemistry(IHC) 3633
Immunochemical staining of human SCGN in human pancreas with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).
Anti-SCGN Antibody Alternative Names
Anti-CALBL Antibody;Anti-DJ501N12.8 Antibody;Anti-SECRET Antibody;Anti-SEGN Antibody;Anti-setagin Antibody
SCGN Background Information

Secretagogin, also known as SCGN, is a secreted protein which is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. Secretagogin / SCGN is widely expressed in prostatic adenocarcinoma as opposed to adenocarcinomas in other organs. The function of Secretagogin / SCGN is unknown, but it has been suggested in beta-cells to influence calcium-influx and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. Secretagogin / SCGN is involved in the calcium metabolism of tumour cells and endothelial cells in a subset of neoplasms of the brain and its coverings. Secretagogin / SCGN is also a novel marker for neuroendocrine differentiation.

Full Name
secretagogin, EF-hand calcium binding protein
  • Birkenkamp-D,K. et al., 2005, Neuroendocrinology. 82 (2):121-38.
  • Skovhus,K.V. et al., 2006, Scand J Immunol. 64 (6):639-45.
  • Pipp,I. et al., 2007, APMIS.115 (4):319-26.
  • Rogstam, A. et al., 2007, Biochem J. 401 (1):353-63.
  • Adolf,K. et al., 2007, Prostate. 67 (5):472-84.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SCGN Antibody Rabbit Monoclonal IHC-P 12411-R048
    Anti-SCGN Antibody Rabbit Polyclonal ELISA 12411-RP01
    Anti-SCGN Antibody Mouse Monoclonal ELISA(Cap) 12411-MM02
    Anti-SCGN Antibody Mouse Monoclonal ELISA,ELISA(Det) 12411-MM04
    Anti-SCGN Antibody Rabbit Polyclonal ELISA,IHC-P 12411-RP02
    Anti-SCGN Antibody Rabbit Monoclonal ELISA 12411-R185
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