SCF / C-kit ligand Protein

Stem Cell Factor

SCF / C-kit ligand Products

SCF / C-kit ligand Protein, Recombinant

Molecule	Species	Description	Cat. No
SCF/C-kit ligand	Human	SCF/C-kit ligand (aa 1-189) Protein, Recombinant	10451-H08B
SCF/C-kit ligand	Mouse	SCF/C-kit ligand Protein, Recombinant	50487-M08B

  10451-H08B: The EC₅₀ for this effect is typically 0.5-5 ng/ml . Measured in a cell proliferation assay using TF­1 human erythroleukemic cells (Kitamura,T. et al. 1989, J. Cell Physiol. 140:323.).

  50487-M08B:

1. Immobilized mouse KITL at 2 µg/ml (100 µl/well) can bind mouse CD117 with a linear ranger of 1.28-32 ng/ml. Measured by its binding ability in a functional ELISA.

2. The EC₅₀ for this effect is typically 0.5-5 ng/ml. Measured in a cell proliferation assay using TF­1 human erythroleukemic cells (Kitamura,T. et al. 1989, J. Cell Physiol. 140:323.).

SCF / C-kit ligand Antibody

Molecule	Application	Description	Cat. No
Mouse SCF/C-kit ligand	WB, ELISA	SCF / C-kit ligand Antibody (Antigen Affinity Purified)	50487-RP02

SCF / C-kit ligand cDNA Clone

Molecule	Species	Description	Cat. No
SCF/C-kit ligand	Human	Human SCF/C-kit ligand cDNA Clone / ORF Clone	HG10451-M
SCF/C-kit ligand	Mouse	Mouse SCF/C-kit ligand cDNA Clone / ORF Clone	MG50487-M

SCF / C-kit ligand Related Areas

Cancer>>Growth Factor & Receptor>>Other>>SCF/C-kit ligand

SCF / C-kit ligand Alternative Names

SCF, C-kit ligand, KITLG, DKFZp686F2250, FPH2, KL-1, Kitl, MGF, SF, SHEP7 [Homo sapiens]

SCF, C-kit ligand, Kitl, Clo, Con, Gb, Kitlg, Mgf, SF, SLF, Sl, Steel, contrasted [Mus musculus]

SCF / C-kit ligand Background

Similar to Kit ligand precursor (C-kit ligand) , also known as Stem cell factor (SCF), Mast cell growth factor (MGF) or Hematopoietic growth factor KL. SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. SCF/C-kit ligand stimulates the proliferation of mast cells. This protein is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It may act synergistically with other cytokines, probably interleukins SCF/C-kit ligand is the ligand for the tyrosine kinase receptor c-kit, which is expressed on both primitive and mature hematopoietic progenitor cells. In vitro, SCF/C-kit ligand synergizes with other growth factors, such as granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage- colony- stimulating factor, and interleukin-3 to stimulate the proliferation and differentiation of cells of the lymphoid, myeloid, erythroid, and megakaryocytic lineages. In vivo, SCF/C-kit also synergizes with other growth factors and has been shown to enhance the mobilization of peripheral blood progenitor cells in combination with G-CSF. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.

SCF / C-kit ligand Related Studies

1. McNiece IK, et al. (1995) Stem cell factor. J Leukoc Biol. 58(1): 14-22.
2. Besmer P, et al. (1993) The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl. 1993:125-37.
3. Mekori YA, et al. (1993) IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand. J Immunol. 151(7): 3775-84.